diff --git a/CMakeLists.txt b/CMakeLists.txt
index 527934d0d4..bebc5b8535 100644
--- a/CMakeLists.txt
+++ b/CMakeLists.txt
@@ -155,6 +155,7 @@ target_architecture(ZDOOM_TARGET_ARCH)
 
 if( ${ZDOOM_TARGET_ARCH} MATCHES "x86_64" )
 	set( HAVE_VM_JIT ON )
+	set( HAVE_VULKAN ON )
 endif()
 
 # no, we're not using external asmjit for now, we made too many modifications to our's.
@@ -180,7 +181,11 @@ if( MSVC )
 	# String pooling
 	# Function-level linking
 	# Disable run-time type information
-	set( ALL_C_FLAGS "/GF /Gy /GR-" )
+	if ( HAVE_VULKAN )
+		set( ALL_C_FLAGS "/GF /Gy /GR- /DHAVE_VULKAN" )
+	else()
+		set( ALL_C_FLAGS "/GF /Gy /GR-" )
+	endif()
 
 	# Use SSE 2 as minimum always as the true color drawers needs it for __vectorcall
 	#set( ALL_C_FLAGS "${ALL_C_FLAGS} /arch:SSE2") # This is already the default
@@ -229,7 +234,12 @@ if( MSVC )
 	string(REPLACE " /GR" " " CMAKE_CXX_FLAGS ${CMAKE_CXX_FLAGS} )
 else()
 	set( REL_LINKER_FLAGS "" )
-	set( ALL_C_FLAGS "-ffp-contract=off" )
+	if ( HAVE_VULKAN )
+		set( ALL_C_FLAGS "-ffp-contract=off -DHAVE_VULKAN" )
+	else()
+		set( ALL_C_FLAGS "-ffp-contract=off" )
+	endif()
+	
 	set( REL_C_FLAGS "" )
 	set( DEB_C_FLAGS "" )
 
@@ -275,9 +285,11 @@ mark_as_advanced( FORCE_INTERNAL_GME )
 option(FORCE_INTERNAL_ASMJIT "Use internal asmjit" ON)
 mark_as_advanced( FORCE_INTERNAL_ASMJIT )
 
-add_subdirectory( glslang/glslang)
-add_subdirectory( glslang/spirv )
-add_subdirectory( glslang/OGLCompilersDLL )
+if (HAVE_VULKAN)
+	add_subdirectory( glslang/glslang)
+	add_subdirectory( glslang/spirv )
+	add_subdirectory( glslang/OGLCompilersDLL )
+endif()
 
 # Fast math flags, required by some subprojects
 set( ZD_FASTMATH_FLAG "" )
diff --git a/src/CMakeLists.txt b/src/CMakeLists.txt
index d5dadc08cd..25c4807387 100644
--- a/src/CMakeLists.txt
+++ b/src/CMakeLists.txt
@@ -460,7 +460,10 @@ add_custom_target( revision_check ALL
 # Libraries ZDoom needs
 
 message( STATUS "Fluid synth libs: ${FLUIDSYNTH_LIBRARIES}" )
-set( ZDOOM_LIBS ${ZDOOM_LIBS} "${ZLIB_LIBRARIES}" "${JPEG_LIBRARIES}" "${BZIP2_LIBRARIES}" "${GME_LIBRARIES}" "${CMAKE_DL_LIBS}" "glslang" "SPIRV" "OGLCompiler" )
+set( ZDOOM_LIBS ${ZDOOM_LIBS} "${ZLIB_LIBRARIES}" "${JPEG_LIBRARIES}" "${BZIP2_LIBRARIES}" "${GME_LIBRARIES}" "${CMAKE_DL_LIBS}" )
+if (HAVE_VULKAN)
+	set( ZDOOM_LIBS ${ZDOOM_LIBS} "glslang" "SPIRV" "OGLCompiler")
+endif()
 include_directories( "${ZLIB_INCLUDE_DIR}" "${BZIP2_INCLUDE_DIR}" "${LZMA_INCLUDE_DIR}" "${JPEG_INCLUDE_DIR}" "${GME_INCLUDE_DIR}" )
 
 if( ${HAVE_VM_JIT} )
@@ -504,8 +507,12 @@ set( PLAT_WIN32_SOURCES
 	win32/gl_sysfb.cpp
 	win32/base_sysfb.cpp
 	win32/win32basevideo.cpp
-	win32/win32glvideo.cpp
-	win32/win32vulkanvideo.cpp )
+	win32/win32glvideo.cpp)
+	
+if (HAVE_VULKAN)
+	set (PLAT_WIN32_SOURCES ${PLAT_WIN32_SOURCES} win32/win32vulkanvideo.cpp )
+endif()
+	
 set( PLAT_POSIX_SOURCES
 	posix/i_cd.cpp
 	posix/i_steam.cpp )
@@ -892,9 +899,10 @@ set( FASTMATH_SOURCES
 	sound/opnmidi/opnmidi_midiplay.cpp
 	sound/opnmidi/opnmidi_opn2.cpp
 	sound/opnmidi/opnmidi_private.cpp
-	sound/opnmidi/wopn/wopn_file.c
-
-	#Vulkan stuff must go into a separate list later because it needs to be disabled for some platforms
+	sound/opnmidi/wopn/wopn_file.c)
+	
+#Vulkan stuff must go into a separate list later because it needs to be disabled for some platforms
+set (VULKAN_SOURCES
 	rendering/vulkan/system/vk_device.cpp
 	rendering/vulkan/system/vk_swapchain.cpp
 	rendering/vulkan/system/vk_builders.cpp
@@ -911,6 +919,10 @@ set( FASTMATH_SOURCES
 	rendering/vulkan/thirdparty/vk_mem_alloc/vk_mem_alloc.cpp
 )
 
+if (HAVE_VULKAN)
+	set (FASTMATH_SOURCES ${FASTMATH_SOURCES} ${VULKAN_SOURCES})
+endif()
+
 set (PCH_SOURCES
 	am_map.cpp
 	b_bot.cpp
diff --git a/src/posix/cocoa/i_video.mm b/src/posix/cocoa/i_video.mm
index 46d7a3a48a..a2606ca40c 100644
--- a/src/posix/cocoa/i_video.mm
+++ b/src/posix/cocoa/i_video.mm
@@ -33,8 +33,10 @@
 
 #include "gl_load/gl_load.h"
 
+#ifdef HAVE_VULKAN
 #define VK_USE_PLATFORM_MACOS_MVK
 #include "volk/volk.h"
+#endif
 
 #include "i_common.h"
 
@@ -811,6 +813,7 @@ void I_SetWindowTitle(const char* title)
 }
 
 
+#ifdef HAVE_VULKAN
 void I_GetVulkanDrawableSize(int *width, int *height)
 {
 	NSWindow* const window = CocoaVideo::GetWindow();
@@ -872,3 +875,4 @@ bool I_CreateVulkanSurface(VkInstance instance, VkSurfaceKHR *surface)
 	const VkResult result = vkCreateMacOSSurfaceMVK(instance, &windowCreateInfo, nullptr, surface);
 	return result == VK_SUCCESS;
 }
+#endif
\ No newline at end of file
diff --git a/src/posix/sdl/sdlglvideo.cpp b/src/posix/sdl/sdlglvideo.cpp
index 188b3c265b..0bfb9976ea 100644
--- a/src/posix/sdl/sdlglvideo.cpp
+++ b/src/posix/sdl/sdlglvideo.cpp
@@ -53,7 +53,9 @@
 #include "gl/system/gl_framebuffer.h"
 #include "gl/shaders/gl_shader.h"
 
+#ifdef HAVE_VULKAN
 #include "rendering/vulkan/system/vk_framebuffer.h"
+#endif
 
 // MACROS ------------------------------------------------------------------
 
@@ -100,9 +102,11 @@ namespace Priv
 	static TOptProc<library, RESULT(*)(__VA_ARGS__)> NAME("SDL_" #NAME)
 
 	SDL2_OPTIONAL_FUNCTION(int,      GetWindowBordersSize,         SDL_Window *window, int *top, int *left, int *bottom, int *right);
+#ifdef HAVE_VULKAN
 	SDL2_OPTIONAL_FUNCTION(void,     Vulkan_GetDrawableSize,       SDL_Window *window, int *width, int *height);
 	SDL2_OPTIONAL_FUNCTION(SDL_bool, Vulkan_GetInstanceExtensions, SDL_Window *window, unsigned int *count, const char **names);
 	SDL2_OPTIONAL_FUNCTION(SDL_bool, Vulkan_CreateSurface,         SDL_Window *window, VkInstance instance, VkSurfaceKHR *surface);
+#endif
 
 #undef SDL2_OPTIONAL_FUNCTION
 
@@ -191,11 +195,14 @@ public:
 	DFrameBuffer *CreateFrameBuffer ();
 
 private:
+#ifdef HAVE_VULKAN
 	VulkanDevice *device = nullptr;
+#endif
 };
 
 // CODE --------------------------------------------------------------------
 
+#ifdef HAVE_VULKAN
 void I_GetVulkanDrawableSize(int *width, int *height)
 {
 	assert(Priv::vulkanEnabled);
@@ -217,6 +224,7 @@ bool I_CreateVulkanSurface(VkInstance instance, VkSurfaceKHR *surface)
 	assert(Priv::window != nullptr);
 	return Priv::Vulkan_CreateSurface(Priv::window, instance, surface) == SDL_TRUE;
 }
+#endif
 
 
 SDLVideo::SDLVideo ()
@@ -233,6 +241,7 @@ SDLVideo::SDLVideo ()
 		Priv::library.Load({ "libSDL2.so", "libSDL2-2.0.so" });
 	}
 
+#ifdef HAVE_VULKAN
 	Priv::vulkanEnabled = vid_backend == 0
 		&& Priv::Vulkan_GetDrawableSize && Priv::Vulkan_GetInstanceExtensions && Priv::Vulkan_CreateSurface;
 
@@ -245,6 +254,7 @@ SDLVideo::SDLVideo ()
 			Priv::vulkanEnabled = false;
 		}
 	}
+#endif
 }
 
 SDLVideo::~SDLVideo ()
@@ -257,6 +267,7 @@ DFrameBuffer *SDLVideo::CreateFrameBuffer ()
 	SystemBaseFrameBuffer *fb = nullptr;
 
 	// first try Vulkan, if that fails OpenGL
+#ifdef HAVE_VULKAN
 	if (Priv::vulkanEnabled)
 	{
 		try
@@ -270,6 +281,7 @@ DFrameBuffer *SDLVideo::CreateFrameBuffer ()
 			Priv::vulkanEnabled = false;
 		}
 	}
+#endif
 
 	if (fb == nullptr)
 	{
@@ -302,8 +314,10 @@ int SystemBaseFrameBuffer::GetClientWidth()
 {
 	int width = 0;
 
+#ifdef HAVE_VULKAN
 	assert(Priv::vulkanEnabled);
 	Priv::Vulkan_GetDrawableSize(Priv::window, &width, nullptr);
+#endif
 
 	return width;
 }
@@ -312,8 +326,10 @@ int SystemBaseFrameBuffer::GetClientHeight()
 {
 	int height = 0;
 
+#ifdef HAVE_VULKAN
 	assert(Priv::vulkanEnabled);
 	Priv::Vulkan_GetDrawableSize(Priv::window, nullptr, &height);
+#endif
 
 	return height;
 }
diff --git a/src/win32/hardware.cpp b/src/win32/hardware.cpp
index 22ccf999e3..014ae6e34f 100644
--- a/src/win32/hardware.cpp
+++ b/src/win32/hardware.cpp
@@ -44,7 +44,9 @@
 #include "m_argv.h"
 #include "version.h"
 #include "win32glvideo.h"
+#ifdef HAVE_VULKAN
 #include "win32vulkanvideo.h"
+#endif
 #include "doomerrors.h"
 #include "i_system.h"
 #include "swrenderer/r_swrenderer.h"
@@ -128,6 +130,7 @@ void I_InitGraphics ()
 		// are the active app. Huh?
 	}
 
+#ifdef HAVE_VULKAN
 	if (vid_backend == 0)
 	{
 		// first try Vulkan, if that fails OpenGL
@@ -141,6 +144,7 @@ void I_InitGraphics ()
 		}
 	}
 	else
+#endif
 	{
 		Video = new Win32GLVideo();
 	}